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Molecular Genetics 4606

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Molecular Genetics 4606

Molecular Genetics is a comprehensive genetics course for molecular genetics majors or biological sciences majors with a genetics focus. Students will integrate genetic, biochemical, and cell-biological data to interpret the normal function of a gene, interpret how mutations affect gene function, and interpret interactions between different genes. Topics include all aspects of transmission genetics and gene biology, including DNA replication, transcription and translation.

Biology
Author
Helen Chamberlin
Publisher
The Ohio State University
Source
LibreTexts
Language
EN
Category
Basic Sciences
Read online Download PDF (open licence)
Contents· 119 sections
  1. 01: The Cell Cycle
  2. 1.01: The Cell Cycle and Changes in DNA Content
  3. 1.02: Bacterial Cell Division and the Eukaryotic Cell Cycle
  4. 1.03: Regulation of the Cell Cycle
  5. 02: Mitosis and Meiosis
  6. 2.01: Mitosis
  7. 2.02: Meiosis
  8. 2.03: Mitosis and Meiosis
  9. 03: Alleles and Probabilities
  10. 3.01: Genes are the Basic Units of Inheritance
  11. 3.02: Model Organisms Facilitate Genetic Advances
  12. 3.03: Mendels First Law
  13. 3.04: Biochemical Basis of Dominance
  14. 3.05: Crossing Techniques Used in Classical Genetics
  15. 3.06: Dihybrid Crosses
  16. 3.07: Why Use Nomenclature
  17. 3.08: Basic Nomenclature
  18. 3.09: Linked Genes
  19. 04: Hypothesis Testing
  20. 4.01: Phenotypic Ratios May Not Be As Expected
  21. 4.02: Probability
  22. 4.03: Chi-Square Test of Goodness-of-Fit
  23. 05: Sex Determination Chromosomes and Linkage
  24. 5.01: Karyotypes Describe Chromosome Number and Structure
  25. 5.02: Sex-Linkage- An Exception to Mendels First Law
  26. 06: Pedigrees
  27. 6.01: Pedigree Analysis
  28. 6.02: Inferring the Mode of Inheritance
  29. 6.03: Sporadic and Non-Heritable Diseases
  30. 6.04: Calculating Probabilities
  31. 07: Multiple Gene Alleles
  32. 7.01: Relationships Between Genes Genotypes and Phenotypes
  33. 7.02: Complementation tests and Allelism
  34. 08: Gene Interactions and Epistasis
  35. 8.01: Epistasis and Other Gene Interactions
  36. 8.02: Example of Multiple Genes Affecting One Character
  37. 09: Genetic Pathways
  38. 9.01: Genetic Pathways
  39. 10: Nucleic Acids
  40. 10.01: DNA is the Genetic Material
  41. 10.02: The Structure of DNA
  42. 10.03: DNA- The Genetic Material
  43. 11: Amplifying and Manipulating DNA Fragments
  44. 11.01: Prelude to Molecular Genetics
  45. 11.02: Isolating Genomic DNA
  46. 11.03: Isolating or Detecting a Specific Sequence by PCR
  47. 11.04: PCR and Gel Electrophoresis
  48. 11.05: Origins of Molecular Polymorphisms
  49. 11.06: Classification and Detection of Molecular Markers
  50. 11.07: Cutting and Pasting DNA- Restriction Digests and DNA Ligation
  51. 11.08: Make and Screen a cDNA Library
  52. 11.09: DNA Sequencing
  53. 11.10: Genomic Libraries
  54. 11.11: The Polymerase Chain Reaction (PCR)
  55. 12: Evaluating Recombinant DNA
  56. 12.01: Cloning DNA - Plasmid Vectors
  57. 12.02: DNA Analysis - Gel Electrophoresis
  58. 12.03: Recombinant DNA Technology
  59. 13: Detecting Genes and Gene Products
  60. 13.01: DNA Analysis- Blotting and Hybridization
  61. 14: DNA Replication
  62. 14.01: DNA Structure
  63. 14.02: Genes and Chromatin in Eukaryotes
  64. 14.03: Introduction
  65. 14.04: DNA Replication
  66. 14.05: DNA- The Genetic Material
  67. 15: Transcription
  68. 15.01: Introduction
  69. 15.02: Overview of Transcription
  70. 15.03: Details of Transcription
  71. 16: Transcriptional Regulation (prokaryotes)
  72. 16.01: The lac Operon
  73. 16.02: The Use of Mutants to Study the lac Operon
  74. 16.03: Gene Regulation in Prokaryotes
  75. 17: RNA processing
  76. 17.01: Details of Eukaryotic mRNA Processing
  77. 17.02: Gene Expression- Transcription
  78. 18: Transcriptional Regulation (eukaryotes)
  79. 18.01: Eukaryotic Gene Regulation
  80. 18.02: Regulatory Elements in Evolution
  81. 18.03: Additional Levels of Regulating Transcription
  82. 18.04: Gene Regulation in Eukaryotes
  83. 18.05: Transgenic organisms
  84. 19: Small RNAs
  85. 19.01: Post-transcriptional Control of Gene Expression
  86. 20: The Genetic Code
  87. 20.01: The Function of Genes
  88. 20.02: An Overview of the Genetic Code
  89. 20.03: Gene and Protein Colinearity and Triplet Codons
  90. 20.04: Translation
  91. 20.05: Gene Expression- Translation
  92. 20.06: Gene Expression- Applied Example (Part 1)
  93. 21: Alleles and Gene Function
  94. 21.01: Types of Mutations
  95. 21.02: DNA Mutations
  96. 22: Cancer Genetics
  97. 22.01: Classification of Cancers
  98. 22.02: Cancer Cell Biology
  99. 22.03: Hallmarks of Cancer
  100. 22.04: Mutagens and Carcinogens
  101. 22.05: Oncogenes
  102. 22.06: Tumor Suppressor Genes
  103. 22.07: The Poster Boy of Genetic Research Leading to a Cancer Treatment Gleevec (Imatinib)
  104. 23: Genomics
  105. 23.01: Omics Technologies
  106. 23.02: DNA Sequencing
  107. 23.03: Whole Genome Sequencing
  108. 24: Functional Genomics
  109. 24.01: Functional Genomics Determining Function(s)
  110. 24.02: Genomic Approaches- The DNA Microarray
  111. 25: Genetic Linkage
  112. 25.01: Linkage
  113. 25.02: Recombination
  114. 25.03: Linkage Reduces Recombination Frequency
  115. 25.04: Crossovers Allow Recombination of Linked Loci
  116. 25.05: Inferring Recombination From Genetic Data
  117. 25.06: Genetic Mapping
  118. 26: Genetic Maps
  119. 26.01: Mapping With Three-Point Crosses