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Catalytic Asymmetric Synthesis
Catalytic asymmetric synthesis the synthesis of compound that favors the formation of a specific enantiomer or diastereomer via catalysis synthetic methods. Enantioselective synthesis is a key process in modern chemistry and is particularly important in the field of pharmaceuticals, as the different enantiomers or diastereomers of a molecule often have different biological activity.
- Author
- Tharmalingam Punniyamurthy
- Publisher
- Indian Institute of Technology Guwahati
- Source
- LibreTexts
- License
- CC BY-SA
- Language
- EN
- Category
- Basic Sciences
Contents· 80 sections
- 01: Reactions using Chiral Lewis Acids and Brnsted Acid
- 1.01: Brnsted Acid-Assisted Lewis Acid (BLA)
- 1.02: Lewis Acid-Assisted Lewis Acid (LLA)
- 1.03: LBA Catalysts
- 1.04: Problems Reference
- 1.05: Chiral Phosphoric Acids (PAs)
- 02: Asymmetric Carbon-Carbon Bond Forming Reactions
- 2.01: Enantioselective Ene and Cycloaddition Reactions
- 2.02: Enantioselective Alkene Metathesis
- 2.03: Carbometallation and Carbocyclization Reactions
- 2.04: Metal-Catalyzed Asymmetric Conjugate Addition Reactions
- 2.05: Allylic Substitution with Carbon Nucleophiles
- 2.06: Problems and Reference
- 03: Synthesis via C-H Activation
- 3.01: Reactions with Metal Carbenoid
- 3.02: Reactions With Metal Nitrenoid and Direct C-H Oxidation
- 3.03: Problems and Reference
- 04: Carbon-Heteroatom Bond-Forming Reactions
- 4.01: Allylic Substitution Reactions
- 4.02: Aza-Claisen Rearrangement and Related Reactions
- 4.03: Hydroamination of Alkenes
- 4.04: Hydroalkoxylation of Allenes
- 4.05: Oxidation Reactions
- 4.06: Aziridination of Alkenes
- 4.07: Amination of Carbonyl Compounds
- 4.08: Boration of Alkenes
- 4.09: Hydrophosphonylation of Imines
- 4.10: Problems and Reference
- 05: Oxidation Reactions
- 5.01: Oxidation of Alcohols
- 5.02: Epoxidation of Allylic Alcohols
- 5.03: Epoxidation of Unfunctionalized Alkenes
- 5.04: Enantioselective Sulfoxidation
- 5.05: Baeyer-Villiger Oxidation (BVO)
- 5.06: Dihydroxylation Aminohydroxylation and Aziridination Reactions
- 5.07: Problems and Reference
- 06: Hydrogenation Reactions
- 6.01: Reactions Carbon-Carbon Double Bonds
- 6.02: Reactions of Ketones
- 6.03: Reactions of Imines (CN)
- 6.04: Problems and Reference
- 07: Reactions in Nonconventional Conditions
- 7.01: Reactions in Water
- 7.02: Reactions in Fluorous Solvents
- 7.03: Reactions in Supercritical Fluids (SCFs)
- 7.04: Reactions in Ionic Liquids (IL)
- 7.05: Microwave-Assisted Reactions
- 7.06: Problems and Reference
- 08: Asymmetric Hydrosilylation and Related Reactions
- 8.01: Hydrosilylation of Alkenes
- 8.02: Hydroboration, Hydroalumination and Hydrostannation of Alkenes
- 8.03: Problems and Reference
- 09: Carbonylation Reactions
- 9.01: Hydroformylation Reaction
- 9.02: Asymmetric Alkoxycarbonylation and Related Reactions
- 9.03: Co- and Terpolymerization of Alkenes with Carbon Monoxide
- 9.04: Problems and Reference
- 10: Organocatalysis
- 10.01: Chiral Proline Based Reactions
- 10.02: Alkaloid Based Reactions
- 10.03: Thiourea Based Catalysis
- 10.04: Problems and Reference
- 11: Enzyme-Catalyzed Asymmetric Reactions
- 11.01: Acylation of Alcohols and Amines
- 11.02: Formation of Carbon-Carbon Bonds
- 11.03: Reduction Reactions
- 11.04: Enantioselective Oxidations
- 11.05: Problems and Reference
- 12: Solutions
- 12.01: Asymmetric Carbon-Carbon Bond Forming Reactions
- 12.02: Asymmetric Hydrosilylation and Related Reactions
- 12.03: Carbon-Heteroatom Bond-Forming Reactions
- 12.04: Carbonylation Reactions
- 12.05: Enzyme-Catalyzed Asymmetric Reactions
- 12.06: Hydrogenation Reactions
- 12.07: Organocatalysis
- 12.08: Oxidation Reactions
- 12.09: Reactions in Nonconventional Conditions
- 12.10: Reactions Using Chiral Lewis and Brønsted Acids
- 12.11: Synthesis via C-H Activation