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Microbiology
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Mục lục· 1016 mục
- 01: Introduction to Microbiology
- 1.01: Introduction to Microbiology
- 1.1A: Defining Microbes
- 1.1B: History of Microbiology - Hooke van Leeuwenhoek and Cohn
- 1.1C: Pasteur and Spontaneous Generation
- 1.1D: Koch and Pure Culture
- 1.02: Microbes and the World
- 1.2.01: 1.2A Types of Microorganisms
- 1.2B: Classification of Microorganisms
- 1.2C: Microbes and the Origin of Life on Earth
- 1.2D: Environmental Diversity of Microbes
- 1.03: The Science of Microbiology
- 1.3.01: 1.3B Applied Microbiology
- 1.3A: Basic Microbiology
- 1.3C: Immunization Antiseptics and Antibiotics
- 1.3D: Modern Microbiology
- 02: Chemistry
- 2.01: Atomic Structure
- 2.1.01: Overview of Atomic Structure
- 2.1.02: Electronic Orbitals
- 2.02: Chemical Bonds
- 2.2.01: Ions and Ionic Bonds
- 2.2.02: Colvalent Bonds and Other Bonds and Interaction
- 2.2.03: Hydrogen Bonding
- 2.2.04: Avogadro's Number and the Mole
- 2.2.05: Average Atomic Mass
- 2.03: Chemical Reactions
- 2.3.01: The Chemical Basis of Life
- 2.3.02: Energy Changes in Chemical Reactions
- 2.04: Inorganic Compounds
- 2.4.01: Water's State- Gas Liquid and Solid
- 2.4.02: pH Buffers Acids and Bases
- 2.4.03: Overview of the Acid- Base Properties of Salt
- 2.05: Organic Compounds
- 2.5.01: Carbohydrate Molecules
- 2.5.02: Lipid Molecules
- 2.5.03: DNA and RNA
- 2.5.04: Amino Acids
- 2.5.05: Types and Functions of Protiens
- 2.5.06: ATP- Adenosine Triphosphate
- 2.06: Energy
- 2.6.01: Metabolism of Carbohydrates
- 2.6.02: Free Energy Changes in Chemical Reactions
- 2.6.03: Internal Energy and Enthaply
- 2.07: Enzymes
- 2.7.01: Control of Metabolism Through Enzyme Regulation
- 2.7.02: Enzyme Active Site and Substrate Specificity
- 03: Microscopy
- 3.01: Looking at Microbes
- 3.1A: Microbe Size
- 3.1B: Units of Measurement for Microbes
- 3.1C: Refraction and Magnification
- 3.1D: Magnification and Resolution
- 3.02: Other Types of Microscopy
- 3.2A: Microscopy
- 3.2B: General Staining Methods
- 3.03: Other Types of Microscopy
- 3.3A: Dark-Field Microscopy
- 3.3B: Phase-Contrast Microscopy
- 3.3C: Interference Microscopy
- 3.3D: Fluorescence Microscopy
- 3.3E: Confocal Micropscopy
- 3.3F: Electron Microscopy
- 3.3G: Scanned-Probe Microscopy
- 3.3H: X-Ray Diffraction Analysis
- 04: Cell Structure of Bacteria Archaea and Eukaryotes
- 4.01: Overview of Prokaryotic and Eukaryotic Cells
- 4.1A: Characteristics of Prokaryotic Cells
- 4.02: The Cytoplasmic Membrane of Prokaryotic and Eukaryotic Cells
- 4.2A: Components of Plasma Membranes
- 4.03: Transport Across the Cell Membrane
- 4.3A: Facilitated Transport
- 4.3B: Primary Active Transport
- 4.3C: ABC Transporters
- 4.3D: Siderophores
- 4.3E: Group Translocation
- 4.04: Cell Walls of Prokaryotes
- 4.4A: The Cell Wall of Bacteria
- 4.4B: Gram-Negative Outer Membrane
- 4.4C: Gram-Positive Cell Envelope
- 4.4D: Mycoplasmas and Other Cell-Wall-Deficient Bacteria
- 4.4E: Cell Walls of Archaea
- 4.4F: Damage of the Cell Wall
- 4.05: Specialized External Structures of Prokaryotes
- 4.5A: Endospores
- 4.06: Specialized Internal Structures of Prokaryotes
- 4.6A: Ribosomes
- 4.6B: Cell Inclusions and Storage Granules
- 4.6C: Carboxysomes
- 4.6D: Magnetosomes
- 4.6E: Gas Vesicles
- 4.07: Internal Structures of Eukaryotic Cells
- 4.7A: The Nucleus and Ribosomes
- 4.7B: Mitochondria
- 4.7C: Comparing Plant and Animal Cells
- 4.7D: The Endoplasmic Reticulum
- 4.7E: The Golgi Apparatus
- 4.08: Other Eukaryotic Components
- 4.8A: Peroxisomes
- 4.8B: Lysosomes
- 4.8C: Intermediate Filaments and Microtubules
- 4.8D: Extracellular Matrix of Animal Cells
- 4.09: Protein Export and Secretion
- 4.9A: Endocytosis
- 4.10: Studying Cells
- 4.10A: Microscopy
- 4.10B: Crystallographic Analysis
- 4.10C: Genetic Analysis
- 05: Microbial Metabolism
- 5.01: Types of Metabolism
- 5.1A: Photoautotrophs and Photohetrotrophs
- 5.1B: Chemoautotrophs and Chemohetrotrophs
- 5.02: Energy Production
- 5.2A: Control of Catabolic Pathways
- 5.2B: Transforming Chemical Energy
- 5.2C: Connecting Other Sugars to Glucose Metabolism
- 5.03: Catabolism
- 5.3A: Types of Catabolism
- 5.3B: Pyruvic Acid and Metabolism
- 5.04: Glycolysis
- 5.4A: Importance of Glycolysis
- 5.4B: Electron Donors and Acceptors
- 5.4C: ATP Yield
- 5.4D: Respiration and Proton Motive Force
- 5.05: Respiratory ETS and ATP Synthase
- 5.5A: Cofactors and Energy Transitions
- 5.5B: Oxidoreductase Protein Complexes
- 5.5C: F10 ATP Synthase
- 5.5D: Sodium Pumps as an Alternative to Proton Pump
- 5.06: The Citric Acid (Krebs) Cycle
- 5.6A: Citric Acid Cycle
- 5.6B: Breakdown of Pyruvate
- 5.6C: Acetyl CoA and the Citric Acid Cycle
- 5.07: Alternatives to Glycolysis
- 5.7A: The Entner-Doudoroff Pathway
- 5.7B: Aerobic Hydrocarbon Oxidation
- 5.7C: The Pentose Phosphate Shunt
- 5.7D: Organic Acid Metabolism
- 5.7E: Lipid Metabolism
- 5.7F: Connecting Proteins to Glucose Metabolism
- 5.7G: Methylotrophy and Methanotrophy
- 5.08: Fermentation
- 5.8A: Anaerobic Cellular Respiration
- 5.8B: Clostridial and Propionic Acid Fermentation
- 5.8C: Fermentation Without Substrate-Level Phosphorylation
- 5.8C: Syntrophy
- 5.09: Anaerobic Respiration
- 5.9A: Electron Donors and Acceptors in Anaerobic Respiration
- 5.9B: Nitrate Reduction and Denitrification
- 5.9C: Sulfate and Sulfur Reduction
- 5.9D: Methanogenesis
- 5.9E: Proton Reduction
- 5.9F: Anoxic Hydrocarbon Oxidation
- 5.10: Chemolithotrophy
- 5.10A: The Energetics of Chemolithotrophy
- 5.10B: Hydrogen Oxidation
- 5.10C: Oxidation of Reduced Sulfur Compounds
- 5.10D: Iron Oxidation
- 5.10E: Nitrification
- 5.10F: Anammox
- 5.10G: Benzoate Catabolism
- 5.10H: Polycyclic Aromatic Hydrocarbons
- 5.11: Phototrophy
- 5.11A: The Purpose and Process of Photosynthesis
- 5.11B: Main Structures and Summary of Photosynthesis
- 5.11C: The Two Parts of Photosynthesis
- 5.11D: Bacteriorhodopsin
- 5.11E: Carotenoids and Phycobilins
- 5.11F: Facultative Phototrophy
- 5.11G: Oxygenic Photosynthesis
- 5.11H: Anoxygenic Photosynthesis
- 5.12: Biosynthesis
- 5.12A: Substrates for Biosysnthesis
- 5.12B: Biosynthesis and Energy
- 5.12C: The Calvin Cycle
- 5.12D: Intermediates Produced During the Calvin Cycle
- 5.12E: Regulation of the Calvin Cycle
- 5.12F: The Reverse TCA Cycle
- 5.12G: The Acetyl-CoA Pathway
- 5.12H: The 3-Hydroxypropionate Cycle
- 5.13: Anabolism
- 5.13A: Polysaccharide Biosynthesis
- 5.13B: Lipid Biosynthesis
- 5.13C: Regulation by Biosynthetic Enzymes
- 5.13D: Bacterial Polyesters
- 5.13E: Polyketide Antibiotics
- 5.14: Amino Acids and Nucleotide Biosynthesis
- 5.14A: Amino Acid Synthesis
- 5.14B: Purine and Pyrimidine Synthesis
- 5.14C: Nonribosomal Peptide Antibiotics
- 5.14D: Biosynthesis of Tetrapyrroles
- 5.15: Nitrogen Fixation
- 5.15A: Nitrogenase and Nitrogen Fixation
- 5.15B: Early Discoveries in Nitrogen Fixation
- 5.15C: Nitrogen Fixation Mechanism
- 5.15D: Anaerobiosis and N Fixation
- 5.15E: Genetics and Regulation of N Fixation
- 06: Culturing Microorganisms
- 6.01: Microbial Nutrition
- 6.1A: Chemical Analysis of Microbial Cytoplasm
- 6.1B: Sources of Essential Nutrients
- 6.1C: Limitation of Microbial Growth by Nutrient Supply
- 6.02: Cell Differentiation and Starvation
- 6.2A: Activation of Starvation by Survival Genes
- 6.2B: Oligotrophs
- 6.2C: Starvation-Induced Fruiting Bodies
- 6.2D: Bacterial Differentiation
- 6.03: Culturing Bacteria
- 6.3A: Culture Media
- 6.3B: Complex and Synthetic Media
- 6.3C: Selective and Differential Media
- 6.3D: Aseptic Technique Dilution Streaking and Spread Plates
- 6.3E: Special Culture Techniques
- 6.04: Microbial Culture Methods
- 6.4A: Enrichment and Isolation
- 6.4B: Pure Culture
- 6.4C: Preserving Bacterial Cultures
- 6.4D: The FISH Technique
- 6.4E: Coupling Specific Genes to Specific Organisms Using PCR
- 6.05: Bacterial Population Growth
- 6.5A: Chemical Assays Radioisotopic Methods and Microelectrodes
- 6.5B: Stable Isotopes
- 6.06: Microbial Growth
- 6.6A: Binary Fission
- 6.6B: Fts Proteins and Cell Division
- 6.6C: MreB and Determinants of Cell Morphology
- 6.6D: Peptidoglycan Synthesis and Cell Division
- 6.6E: Generation Time
- 6.07: Bacterial Population Growth
- 6.7A: Microbial Growth Cycle
- 6.7B: Growth Terminology
- 6.08: Counting Bacteria
- 6.8A: Direct Counting
- 6.8B: Viable Cell Counting
- 6.8C: Measurements of Microbial Mass
- 6.8D: Detecting Acid and Gas Production
- 6.09: Temperature and Microbial Growth
- 6.9A: Growth Rate and Temperature
- 6.9B: Classification of Microorganisms by Growth Temperature
- 6.9C: The Heat-Shock Response
- 6.10: Other Environmental Growth Factors
- 6.10A: Gas Requirements
- 6.10B: Osmotic Pressure
- 6.10C: Microbial Growth at Low or High pH
- 6.10D: Oxygen
- 6.11: Microbial Growth in Communities
- 6.11A: Ecological Associations Among Microorganisms
- 6.11B: Biofilms
- 6.12: Control in Microbial Death
- 6.12A: Considerations in Microbial Control
- 6.12B: Rate of Microbial Death
- 6.12C: Relative Resistance of Microbes
- 6.13: Mechanisms of Microbial Control
- 6.13A: Alteration of Membrane Permeability
- 6.13B: Damage to Proteins and Nucleic Acids
- 6.14: Physical Antimicrobial Control
- 6.14A: Heat
- 6.14B: Radiation
- 6.14C: Low Temperatures
- 6.14D: High Pressure
- 6.14E: Desiccation
- 6.14F: Osmotic Pressure
- 6.14G: Filtration
- 6.15: Chemical Antimicrobial Control
- 6.15A: Effective Disinfection
- 6.15B: Factors that Affect Germicidal Activity of Chemicals
- 6.15C: Types of Disinfectants
- 6.15D: Biological Control of Microbes
- 07: Microbial Genetics
- 7.01: Genes
- 7.1A: Bacterial Genomes
- 7.1B: DNA Replication in Prokaryotes
- 7.1C: Gene Inversion
- 7.1D: Slipped-Strand Mispairing
- 7.02: Prokaryotic Genomes
- 7.2A: Bacterial Chromosomes in the Nucleoid
- 7.2B: Supercoiling
- 7.2C: Size Variation and ORF Contents in Genomes
- 7.2D: Bioinformatic Analyses and Gene Distributions
- 7.03: DNA Replication
- 7.3A: Basics of DNA Replication
- 7.3B: DNA Replication in Eukaryotes
- 7.04: Plasmids
- 7.4A: Introduction to Plasmids
- 7.4B: Types of Plasmids and Their Biological Significance
- 7.05: RNA Synthesis - Transcription
- 7.5A: Elongation and Termination in Eukaryotes
- 7.5B: The Promoter and the Transcription Machinery
- 7.06: Translation- Protein Synthesis
- 7.6A: Processing of tRNAs and rRNAs
- 7.6B: The Protein Synthesis Machinery
- 7.6C: Prokaryotic Transcription and Translation Are Coupled
- 7.6D: The Incorporation of Nonstandard Amino Acids
- 7.6E: Unsticking Stuck Ribosomes
- 7.07: Protein Modification Folding Secretion and Degradation
- 7.7A: mRNA Processing
- 7.7B: Denaturation and Protein Folding
- 7.7C: Protein Folding Modification and Targeting
- 7.7D: Regulating Protein Activity and Longevity
- 7.08: Archaeal Genetics
- 7.8A: Chromosomes and DNA Replication in the Archaea
- 7.8B: Shared Features of Bacteria and Archaea
- 7.8C: Shared Features of Archaea and Eukaryotes
- 7.09: Eukaryotic Genetics
- 7.9A: The Role of the Cell Cycle
- 7.9B: The Relationship Between Genes and Proteins
- 7.10: Mutation
- 7.10A: DNA Repair
- 7.11: Genetic Transfer in Prokaryotes
- 7.11A: Generalized Recombination and RecA
- 7.11B: Bacterial Transformation
- 7.11C: Bacterial Transduction
- 7.11D: Prokaryotic Reproduction
- 7.11E: Complementation
- 7.11F: Gene Transfer in Archaea
- 7.12: Tools of Genetic Engineering
- 7.12A: Recombinant DNA Technology
- 7.12B: Selection
- 7.12C: Mutation
- 7.12D: Reproductive Cloning
- 7.12E: Basic Techniques to Manipulate Genetic Material (DNA and RNA)
- 7.12F: Molecular and Cellular Cloning
- 7.12G: Plasmids as Cloning Vectors
- 7.13: Bioinformatics
- 7.13A: Strategies Used in Sequencing Projects
- 7.13B: Annotating Genomes
- 7.13C: Homologs Orthologs and Paralogs
- 7.13D: Synthesizing DNA
- 7.13E: Amplifying DNA - The Polymerase Chain Reaction
- 7.13F: DNA Sequencing Based on Sanger Dideoxynucleotides
- 7.13G: Metagenomics
- 7.13H: Reporter Fusions
- 7.14: Cloning Techniques
- 7.14A: Putting Foreign DNA into Cells
- 7.14B: Obtaining DNA
- 7.14C: Hosts for Cloning Vectors
- 7.14D: Shuttle Vectors and Expression Vectors
- 7.14E: Bacteriophage Lambda as a Cloning Vector
- 7.14F: Vectors for Genomic Cloning and Sequencing
- 7.15: Genome Evolution
- 7.15A: Gene Families
- 7.15B: Genomics and Biofuels
- 7.15C: Genome Reduction
- 7.15D: Pathogenicity Islands
- 7.16: Environmental Genomics
- 7.16A: Detecting Uncultured Microorganisms
- 7.16B: Viral Genomes in Nature
- 7.17: Molecular Regulation
- 7.17A: Catabolite Activator Protein (CAP) - An Activator Regulator
- 7.17B: The Initiation Complex and Translation Rate
- 7.18: Global Regulatory Mechanisms
- 7.18A: Transcription in Prokaryotes
- 7.18B: The trp Operon - A Repressor Operon
- 7.18C: The Stringent Response
- 7.18D: Repression of Anabolic Pathways
- 7.18E: The AraC Regulator
- 7.19: RNA-Based Regulation
- 7.19A: RNA Regulation and Antisense RNA
- 7.19B: Attenuation
- 7.19C: Riboswitches
- 7.19D: Regulation of Sigma Factor Activity
- 7.19E: Regulation of Sigma Factor Translation
- 7.19F: Proteolytic Degradation
- 7.19G: Small Regulatory RNAs
- 7.20: Developmental Regulation
- 7.20A: Sporulation in Bacillus
- 7.20B: Caulobacter Differentiation
- 7.21: Sensing and Signal Transduction
- 7.21A: Chemotaxis
- 7.21B: Two-Component Regulatory Systems
- 7.21C: Quorum Sensing
- 7.21D: Control of Transcription in Archaea
- 7.22: Genomics and Proteomics
- 7.22A: Microarrays and the Transcriptome
- 7.22B: Proteomics
- 7.22C: Metabolomics
- 7.23: Genetic Engineering Products
- 7.23A: Overview of Biotechnology
- 7.23B: Applications of Genetic Engineering
- 7.23C: Biochemical Products of Recombinant DNA Technology
- 7.23D: Mammalian Gene Expression in Bacteria
- 7.23E: Mammalian Proteins and Products
- 7.24: Transgenic Organisms
- 7.24A: Genetically Engineered Vaccines
- 7.24B: Genetic Engineering in Animals
- 7.24C: Biotechnology in Medicine
- 7.25: Molecular Techniques
- 7.25A: Inactivating and Marking Target Genes with Transposons
- 7.25B: DNA Sequencing of Insertion Sites
- 7.25C: Northern Blots
- 7.25D: Western Bolts
- 7.25E: DNA Mobility Shifts
- 7.25F: Purifying Proteins by Affinity Tag
- 7.25G: Primer Extension Analysis
- 7.25H: DNA Protection Analysis
- 7.25I: Whole-Genome DNA-Binding Analysis
- 7.25J: Two-Hybrid Analysis
- 7.26: Cell Physiology Techniques
- 7.26.01: 7. 26B- Tracking Cells with Light
- 7.26.02: 7. 26C- Multiplex and Real-Time PCR
- 7.26A: Mapping Protein-Protein Interactions
- 7.26D: Phase Display
- 08: Microbial Evolution Phylogeny and Diversity
- 8.01: Origins of Life
- 8.1A: Evidence of Evolution
- 8.1B: Elements of Life
- 8.1C: Unresolved Questions About the Origins of Life
- 8.02: Astrobiology
- 8.2A: Mars and a Biosphere
- 8.2B: Martian Biosignatures
- 8.2C: Terraforming Mars
- 8.2D: Europa's Possible Ocean
- 8.03: Microbial Phylogeny
- 8.3A: Processes and Patterns of Evolution
- 8.3B: Distinguishing between Similar Traits
- 8.3C: The Levels of Classification
- 8.04: Classification of Microorganisms
- 8.4A: The Taxonomic Scheme
- 8.4B: The Diagnostic Scheme
- 8.4C: The Species Concept in Microbiology
- 8.4D: Classification and Nomenclature
- 8.05: Methods of Classifying and Identifying Microorganisms
- 8.5A: Phenotypic Analysis
- 8.5B: Classification of Prokaryotes
- 8.5C: Phylogenetic Analysis
- 8.5D: Nongenetic Categories for Medicine and Ecology
- 8.06: Bacterial Diversity
- 8.6A: Common Bacterial Traits
- 8.6C: Unclassified and Uncultured Bacteria
- 8.07: Proteobacteria
- 8.7A: Overview of Proteobacteria
- 8.7B: Alphaproteobacteria
- 8.7C: Betaproteobacteria
- 8.7D: Morphologically Unusual Proteobacteria
- 8.7E: Gammaproteobacteria
- 8.7F: Deltaproteobacteria
- 8.7G: Epsilonproteobacteria
- 8.08: Gram-Positive Bacteria and Actinobacteria
- 8.8A: Overview of Gram-Positive Bacteria and Actinobacteria
- 8.8B: Non-Spore-Forming Firmicutes
- 8.8C: Firmicutes
- 8.8D: Actinobacteria (High G C Gram-Positive Bacteria)
- 8.09: Nonproteobacteria Gram-Negative Bacteria
- 8.9A: Cyanobacteria
- 8.9B: Anoxygenic Photosynthetic Bacteria
- 8.9C: Prochlorophytes
- 8.10: Irregular Bacterial cells
- 8.10A: Chlamydiae
- 8.10B: Planctomycetes
- 8.10C: Verrucomicrobia
- 8.11: Other Bacterial Groups
- 8.11A: Bacteroides and Flavobacterium
- 8.11B: Acidobacteria
- 8.11C: Cytophaga and Relatives
- 8.11D: Bacteroidetes and Chlorobi
- 8.11E: Fusobacteria
- 8.11F: Spirochaetes
- 8.12: Thermophiles
- 8.12A: Aquificales and Thermotogales
- 8.12B: Deinococcus and Thermus
- 8.12C: Chloroflexus and Relatives
- 8.12D: Nitrospirae and Deferribacter
- 8.12E: Aquifex Thermocrinis and Related Bacteria
- 8.13: Archaeal Diversity
- 8.13A: Energy Conservation and Autotrophy in Archaea
- 8.13B: Archaeal Gene Regulation
- 8.14: Crenarchaeota
- 8.14A: Habitats and Energy Metabolism of Crenarchaeota
- 8.14B: Hyperthermophiles from Terrestrial Volcanic Habitats
- 8.14C: Hyperthermophiles from Submarine Volcanic Habitats
- 8.14D: Nonthermophilic Crenarchaeota
- 8.14E: Psychrophilic Crenarchaeota
- 8.15: Euryarchaeota
- 8.15A: Diverse Cell Forms of Methanogens
- 8.15B: Extremely Halophilic Archaea
- 8.15C: Methane-Producing Archaea - Methanogens
- 8.15D: Thermoplasmatales Thermocaccales and Methanopyrus
- 8.15E: Archaeoglobus
- 8.15F: Nanoarchaeum and Aciduliprofundum
- 8.15G: Hyperthermophilic Archaea H and Microbial Evolution
- 8.16: Eukaryotic Microbial Diversity
- 8.16A: Phylogeny of the Eukarya
- 8.16B: Historical Overview of Eukaryotes
- 8.16C: Opisthokonts - Animals and Fungi
- 8.16D: Endosymbiotic Theory and the Evolution of Eukaryotes
- 8.16E: Cell Structure Metabolism and Motility
- 8.16F: Newly Discovered Eukaryotes
- 8.17: Fungi
- 8.17A: Characteristics of Fungi
- 8.17B: Fungi as Plant Animal and Human Pathogens
- 8.17C: Fungi Habitat Decomposition and Recycling
- 8.17D: Chytridiomycota - The Chytrids
- 8.17E: Zygomycota - The Conjugated Fungi
- 8.17F: Glomeromycota
- 8.17G: Ascomycota - The Sac Fungi
- 8.17H: Basidiomycota - The Club Fungi
- 8.18: Protists
- 8.18A: Early Eukaryotes
- 8.18B: Excavata
- 8.18C: Chromalveolata- Alveolates
- 8.18D: Chromalveolata- Stramenopiles
- 8.18E: Rhizaria
- 8.18F: Amoebozoa and Opisthokonta
- 8.19: Algae
- 8.19A: Archaeplastida
- 8.19B: Protists as Primary Producers Food Sources and Symbionts
- 8.20: Helminths
- 8.20A: Characteristics of Helminths
- 8.20B: Classification and Identification of Helminths
- 8.20C: Distribution and Importance of Parasitic Worms
- 8.20D: Arthropods as Vectors
- 09: Viruses
- 9.01: Overview of Viruses
- 9.1A: Discovery and Detection of Viruses
- 9.1B: Nature of the Virion
- 9.1C: Viral Genomes
- 9.1D: Host Range
- 9.1E: Viral Size
- 9.02: Structure of Viruses
- 9.2A: Viral Morphology
- 9.2B: General Morphology
- 9.2C: Complex and Asymmetrical Virus Particles
- 9.03: Classifying Viruses
- 9.3A: The International Committee on Taxonomy of Viruses
- 9.3B: The Baltimore Virus Classification
- 9.3C: Evolution of Viruses
- 9.3D: Medical Importance of Viruses
- 9.04: Culturing Viruses
- 9.4A: Batch Culture of Bacteriophages
- 9.4B: Tissue Culture of Animal Viruses
- 9.4C: Inoculation of Live Animals
- 9.4D: Viral Identification
- 9.05: Viral Replication
- 9.5A: General Features of Virus Replication
- 9.5B: Steps of Virus Infections
- 9.5C: Tissue Tropism in Animal Viruses
- 9.5D: Animal Viruses
- 9.5E: Plant Virus Life Cycles
- 9.06: Subviral Entities
- 9.6A: Defective Viruses
- 9.6B: Viroids
- 9.6C: Prions
- 9.07: Viral Diversity
- 9.7A: Overview of Bacterial Viruses
- 9.7B: RNA Bacteriophages
- 9.7C: Single-Stranded DNA Bacteriophages
- 9.7D: Double-Stranded DNA Bacteriophages
- 9.7E: Mu- A Double-Stranded Transposable DNA Bacteriophage
- 9.7F: Virulent Bacteriophages and T4
- 9.7G: Temperate Bacteriophages - Lambda and P1
- 9.7H: Viruses of Archaea
- 9.08: Positive-Strand RNA Viruses in Animals
- 9.8A: Positive-Strand RNA Viruses of Animals
- 9.8B: Virus Attachment and Genome Entry
- 9.8C: Viral Replication and Gene Expression
- 9.8D: Viral Exit
- 9.09: Negative-Strand RNA Viruses in Animals
- 9.9A: Negative-Strand RNA Viruses of Animals
- 9.9B: Attachment and Entry to the Host Cell
- 9.9C: Replicative Cycle of Influenza A
- 9.10: Retroviruses- Double-Stranded RNA Viruses
- 9.10A: Double-Stranded RNA Viruses - Retroviruses
- 9.10B: HIV Attachment and Host Cell Entry
- 9.10C: Retroviral RNA Genome
- 9.10D: Replicative Cycle of HIV
- 9.11: DNA Viruses in Eukaryotes
- 9.11A: Plant DNA Viruses
- 9.11B: Replication of Double-Stranded DNA Viruses of Animals
- 9.11C: Double-Stranded DNA Viruses - Herpesviruses
- 9.11E: Attachment and Entry of Herpes Simplex
- 9.11E: Replication of Herpes Simplex Virus
- 9.11F: Immunodeficiency
- 9.11G: Double-Stranded DNA Viruses - Pox Viruses
- 9.11H: Double-Stranded DNA Viruses- Adenoviruses
- 9.11I: Retroviruses and Hepadnavirus
- 9.11J: Treatment of Animal Viral Infections
- 9.12: Viruses and Cancer
- 9.12A: Cancer Viruses
- 9.12B: DNA Oncogenic Viruses
- 9.12C: RNA Oncogenic Viruses
- 9.13: Viral Ecology
- 9.13A: Emergence of Viral Pathogens
- 9.13B: Viral Roles in Ecosystems
- 10: Epidemiology
- 10.01: Principles of Epidemiology
- 10.1A: History of Epidemiology
- 10.1B: The Science of Epidemiology
- 10.1C: The Vocabulary Epidemiology
- 10.1D: Kochs Postulates
- 10.1E: Exceptions to Kochs Postulates
- 10.02: Pathogen Identification
- 10.2A: Occurrence of a Disease
- 10.2B: Disease Severity and Duration
- 10.2C: Extent of Host Involvement
- 10.2D: Identification of Microbes Based on Molecular Genetics
- 10.03: Disease Patterns
- 10.3A: Predisposing Factors
- 10.3B: Disease Development
- 10.3C: Disease Reservoirs and Epidemics
- 10.3D: Infectious Disease Transmission
- 10.3E: Ecology Epidemiology and Evolution of Pathogens
- 10.3F: Safety in the Microbiology Laboratory
- 10.3G: Finding Patient Zero and Tracking Diseases
- 10.04: Nosocomial Infections
- 10.4A: Microorganisms in the Hospital
- 10.4B: Compromised Host
- 10.4C: Chain of Transmission
- 10.4D: Control of Nosocomial Infections
- 10.05: Epidemiology and Public Health
- 10.5A: Descriptive Epidemiology
- 10.5B: Analytical Epidemiology
- 10.5C: Experimental Epidemiology
- 10.5D: Public Health Measures for Disease Control
- 10.5E: Global Health
- 10.5F: Emerging and Reemerging Infectious Diseases
- 10.5G: Biological Weapons
- 10.5H: Technology and New Infectious Agents
- 10.5I: Current Epidemics
- 11: Immunology
- 11.01: Overview of Immunity
- 11.1A: Cells and Organs of the Immune System
- 11.1B: Overview of Human-Microbial Reactions
- 11.1C: Overview of the Immune System
- 11.02: The Innate Immune Response
- 11.2A: Natural Killer Cells
- 11.2B: Physical and Chemical Barriers
- 11.2C: The Complement System
- 11.2D: Pathogen Recognition
- 11.03: Phagocytes
- 11.3A: Phagocyte Migration and Phagocytosis
- 11.3B: Antigen-presenting Cells - B and T cells
- 11.04: Innate Defenders
- 11.4A: The Complement System
- 11.4B: Interferons
- 11.4C: Natural Killer Cells
- 11.4D: Toll-Like Receptors
- 11.4E: Iron-Binding Proteins
- 11.4F: Antimicrobial Peptides
- 11.4G: The Complement System and Heart Disease
- 11.05: The Adaptive Immune Response
- 11.5A: Humoral Immune Response
- 11.5B: Development of the Dual Lymphocyte System
- 11.06: Antigens and Antibodies
- 11.6A: Immunodeficiency
- 11.6B: Antibody Functions
- 11.07: Antibodies
- 11.7A: Antibody Proteins and Antigen Binding
- 11.7B: Antibody Genes and Diversity
- 11.7C: Clonal Selection of Antibody-Producing Cells
- 11.7D: Isotype Class Switching
- 11.7E: Making Memory B Cells
- 11.7F: Primary and Secondary Antibody Responses
- 11.08: T Cells and Cellular Immunity
- 11.8A: Cytotoxic T Lymphocytes and Mucosal Surfaces
- 11.8B: Classes of T Cells
- 11.8C: Cell-Mediated Immunity
- 11.8D: Regulatory T Cells
- 11.8E: T Cell Receptors
- 11.8F: Adaptive Immunity and the Immunoglobulin Superfamily
- 11.09: Antigen-Presenting Cells
- 11.9A: Dendritic Cells
- 11.9B: Macrophages
- 11.10: Immunity and Molecular Signals
- 11.10A: Clonal Selection and Tolerance
- 11.10B: Cytokines and Chemokines
- 11.10C: Superantigens
- 11.10D: The Complement System
- 11.11: The Major Histocompatibility Complex (MHC)
- 11.11A: MHC Polymorphism and Antigen Binding
- 11.12: Classifying Immunities
- 11.12A: Natural Active Immunity
- 11.12B: Natural Passive Immunity
- 11.12C: Artificial Immunity
- 12: Immunology Applications
- 12.01: Immunization
- 12.1A: Passive Immunization
- 12.1B: Vaccination
- 12.1C: Development of New Vaccines
- 12.1D: Vaccine Safety
- 12.02: Immunoassays for Disease
- 12.2A: Immunoassays for Disease
- 12.2B: Antibody Functions
- 12.2C: Serology
- 12.2D: Precipitation Reactions
- 12.2E: Agglutination Reactions
- 12.2F: Neutralization Reaction
- 12.2G: Complement Fixation
- 12.2H: Fluorescent Antibodies
- 12.2I: Enzyme-Linked Immunosorbent Assay (ELISA)
- 12.2J: Immunoblot Procedures
- 12.2K: Tests That Differentiate Between T Cells and B cells
- 12.2L: In Vivo Testing
- 12.2M: The Future of Diagnostic Immunology
- 12.03: Preparations for Diagnosing Infection
- 12.3A: Specimen Collection
- 12.3B: Immediate Direct Examination of Specimen
- 12.3C: Cultivation of Specimen
- 12.3D: DNA Analysis Using Genetic Probes and PCR
- 12.3E: Nucleic Acid Sequencing and rRNA Analysis
- 12.04: Immunity Disorders- Hypersensitivity
- 12.4A: Type I (Anaphylactic) Reactions
- 12.4B: Diagnosis and Treatment of Allergy
- 12.4C: Type II (Cytotoxic) Reactions
- 12.4D: Type III (Immune Complex) Reactions
- 12.4E: Type IV (Delayed Cell-Mediated) Reactions
- 12.05: Immunity Disorders- Autoimmune Diseases
- 12.5A: Immunodeficiency
- 12.5B: The Roles of Genetics and Gender in Autoimmune Disease
- 12.5C: Cytotoxic Autoimmune Reactions
- 12.5D: Immune Complex Autoimmune Reactions
- 12.5E: Cell-Mediated Autoimmune Reactions
- 12.06: Immunity Disorders- Immunodeficiencies
- 12.6A: Primary Immunodeficiency Diseases
- 12.6B: Secondary Immunodeficiency Diseases
- 12.6C: Immunotherapy for Cancer
- 13: Antimicrobial Drugs
- 13.01: Overview of Antimicrobial Therapy
- 13.1A: Origins of Antimicrobial Drugs
- 13.1B: Antibiotic Discovery
- 13.1C: Antibiotics and Selective Toxicity
- 13.1D: Spectrum of Antimicrobial Activity
- 13.1E: Antibiotic Classifications
- 13.02: Functions of Antimicrobial Drugs
- 13.2A: Inhibiting Cell Wall Synthesis
- 13.2B: Injuring the Plasma Membrane
- 13.2C: Inhibiting Nucleic Acid Synthesis
- 13.2D: Inhibiting Protein Synthesis
- 13.2E: Inhibiting Essential Metabolite Synthesis
- 13.03: Commonly Used Antimicrobial Drugs
- 13.3A: Synthetic Antimicrobial Drugs
- 13.3B: Naturally Occurring Antimicrobial Drugs- Antibiotics
- 13.3C: Beta-Lactam Antibiotics- Penicillins and Cephalosporins
- 13.3D: Antibiotics from Prokaryotes
- 13.3E: Antimycobacterial Antibiotics
- 13.04: Interactions Between Drug and Host
- 13.4A: Organ Toxicity
- 13.4B: Allergic Responses to Drugs
- 13.4C: Suppression and Alteration of Microbiota by Antimicrobials
- 13.4D: Effects of Drug Combinations
- 13.05: Measuring Drug Susceptibility
- 13.5A: Minimal Inhibitory Concentration (MIC)
- 13.5B: Kirby-Bauer Disk Susceptibility Test
- 13.06: Drug Resistance
- 13.6A: Mechanisms of Resistance
- 13.6B: Antibiotic Misuse
- 13.6C: Cost and Prevention of Resistance
- 13.6D: Biofilms Persisters and Antibiotic Tolerance
- 13.6E: Finding New Antimicrobial Drugs
- 13.6F: Antimicrobial Peptides
- 13.6G: Antisense Agents
- 13.07: Antiviral Drugs
- 13.7A: Antiviral Agents that Prevent Virus Uncoating or Release
- 13.7B: Antiviral DNA Synthesis Inhibitors
- 13.7C: Nucleotide and Nonnucleotide Reverse Transcriptase Inhibitors
- 13.7D: Protease Inhibitors
- 13.08: Other Antimicrobial Drugs
- 13.8A: Antifungal Drugs
- 13.8B: Antiprotozoan and Antihelminthic Drugs
- 14: Pathogenicity
- 14.01: Entry into the Host
- 14.1A: Portals of Microbe Entry
- 14.1B: Colonization and Growth
- 14.1C: Pathogenicity Islands and Virulence Factors
- 14.1D: Adherence
- 14.1E: Host Risk Factors
- 14.1F: Innate Resistance
- 14.02: Overview of Microbe-Host Interactions
- 14.2A: Normal Microbiota and Host Relationships
- 14.2B: Opportunistic Microorganisms
- 14.2C: Cooperation Among Microorganisms
- 14.03: Penetrating Host Defenses
- 14.3A: Penetrating Host Defenses
- 14.3B: Pili and Pilus Assembly
- 14.3C: Biofilms and Infections
- 14.04: Damaging Host Cells
- 14.4A: Toxins
- 14.4B: Direct Damage
- 14.4C: Type III and Type IV Secretion
- 14.4D: Plasmids and Lysogeny
- 14.4E: Siderophores
- 14.05: Surviving Within the Host and Exiting the Host
- 14.5A: Intracellular Pathogens
- 14.5B: Extracellular Immune Avoidance
- 14.5C: Regulating Virulence
- 14.5D: Portals of Exit
- 14.06: Pathogenicity and Other Microbes
- 14.6A: Fungi
- 14.6B: Protozoa
- 14.6C: Helminths
- 14.6D: Algae
- 15: Diseases
- 15.01: Protozoan and Helminthic Diseases of the Cardiovascular and Lymphatic Systems
- 15.1A: Chagas Disease (American Trypanosomiasis)
- 15.1B: Toxoplasmosis
- 15.1C: Malaria
- 15.1D: Leishmaniasis
- 15.1E: Babesiosis
- 15.1F: Schistosomiasis
- 15.1G: Swimmers Itch
- 15.02: Microbial Diseases of the Respiratory System
- 15.2A: Functional Anatomy of the Respiratory System
- 15.2B: Airborne Transmission of Disease
- 15.03: Bacterial Diseases of the Respiratory System
- 15.3A: Pharyngitis
- 1.01: Scarlet Fever
- 15.3C: Diphtheria
- 15.3D: Otitis Media
- 15.3E: Whooping Cough
- 15.3F: Tuberculosis
- 15.3G: Bacterial Pneumonias
- 15.04: Viral Diseases of the Respiratory System
- 15.4A: Colds
- 15.4B: Viral Pneumonia
- 15.4C: Respiratory Syncytial Virus Infection
- 15.4D: Coryza and Influenza
- 15.05: Fungal Diseases of the Respiratory System
- 15.5A: Histoplasmosis
- 15.5B: Coccidiomycosis
- 15.5C: Pneumocystis Pneumonia
- 15.5D: Blastomycosis
- 15.5E: Other Fungi Involved in Respiratory Disease
- 15.06: Microbial Diseases of the Digestive System
- 15.6A: Anatomy of the Digestive System
- 15.6B: Normal Gastrointestinal Microbiota
- 15.07: Bacterial Diseases of the Mouth
- 15.7A: Tooth and Gum Infections
- 15.7B: Dental Caries
- 15.7C: Periodontal Disease
- 15.08: Bacterial Diseases of the Digestive System
- 15.8A: Bacterial Gastroenteritis
- 15.8B: Staphylococcal Food Poisoning
- 15.8C: Salmonellosis
- 15.8D: Typhoid Fever
- 15.8E: Cholera
- 15.8F: Noncholera Vibrios
- 15.8G: Pathogenic Escherichia coli
- 15.8H: Campylobacter
- 15.8I: Peptic Ulcer Disease
- 15.8J: Listeriosis
- 15.09: Viral Diseases of the Digestive System
- 15.9A: Mumps
- 15.9B: Hepatitis
- 15.9C: Viral Gastroenteritis
- 15.10: Fungal and Protozoan Diseases of the Digestive System
- 15.10A: Ergot Poisoning
- 15.10B: Aflatoxin Poisoning
- 15.10C: Giardiasis
- 15.10D: Cryptosporidiosis
- 15.10E: Cyclospora Diarrheal Infection
- 15.10F: Amoebic Dysentery (Amoebiasis)
- 15.10G: Legionellosis
- 15.11: Diagnosing Microbial Diseases
- 15.11A: Diagnosing Microbial Diseases
- 15.12: Helminthic Diseases of the Digestive System
- 15.12A: Tapeworms
- 15.12B: Hydatid Disease
- 15.12C: Nematodes
- 15.13: Microbial Diseases of the Genitourinary System
- 15.13A: Overview of the Male and Female Reproductive Systems
- 15.13B: Overview of the Urinary System
- 15.13C: Normal Genitourinary Microbiota
- 15.14: Bacterial Diseases of the Urinary System
- 15.14A: Urinary Tract Infection (UTI)
- 15.14B: Cystitis
- 15.14C: Pyelonephritis
- 15.14D: Leptospirosis
- 15.15: Bacterial Diseases of the Reproductive System
- 15.15A: Prostatitis
- 15.15B: Prostatitis
- 15.15C: Gonorrhea
- 15.15D: Nongonococcal Urethritis (NGU)
- 15.15E: Pelvic Inflammatory Disease (PID)
- 15.15F: Syphilis
- 15.15G: Genital Ulcer Diseases
- 15.15H: Lymphogranuloma Venereum
- 15.15I: Group B Streptococcus Colonization
- 15.15J: Chancroid (Soft Chancre)
- 15.15K: Bacterial Vaginosis
- 15.15L: Chlamydia
- 15.16: Viral Diseases of the Reproductive System
- 15.16A: Genital Herpes
- 15.16B: Genital Warts
- 15.16C: HIV and AIDS
- 15.16D: Human Papillomavirus (HPV)
- 15.17: Fungal and Protozoan Diseases of the Reproductive System
- 15.17A: Vulvovaginal Candidiasis
- 15.17B: Trichomoniasis
- 15.17C: The TORCH Panel of Tests
- 15.18: Microbial Diseases of the Skin
- 15.18A: Structure of the Skin- Epidermis
- 15.18B: Microbiota of the Skin
- 15.18C: Bacterial Skin Diseases
- 15.18D: Viral Skin Diseases
- 15.18E: Fungal Skin and Nail Diseases
- 15.18F: Parasitic Skin Diseases
- 15.19: Microbial Diseases of the Eye
- 15.19A: Anatomy of the Eye
- 15.19B: Normal Eye Microbiota
- 15.19C: Bacterial Eye Diseases
- 15.19D: Other Infectious Eye Diseases
- 15.20: Microbial Diseases of the Nervous System
- 15.20A: Functions of the Nervous System
- 15.20B: Subdivisions of the Nervous System
- 15.20C: Meningitis
- 15.20D: Botulism
- 15.20E: Leprosy
- 15.20F: Tetanus
- 15.20G: Paralysis-Causing Bacterial Neurotoxins
- 15.21: Other Diseases of the Nervous System
- 15.21A: Rabies
- 15.21B: Poliomyelitis
- 15.21C: Hantavirus
- 15.21D: Arboviral Encephalitis
- 15.21E: Rickettsial Diseases
- 15.21F: Lyme Disease
- 15.21G: West Nile Virus
- 15.21H: Plague
- 15.22: Fungal Protozoan Prion and Other Diseases of the Nervous System
- 15.22A: Cryptococcosis
- 15.22B: African Trypanosomiasis
- 15.22C: Amoebic Meningoencephalitis
- 15.22D: Bovine Spongiform Encephalopathy
- 15.22E: Variant Creutzfeldt-Jakob Disease
- 15.22F: Chronic Fatigue Syndrome
- 15.23: Microbial Diseases of the Cardiovascular and Lymphatic Systems
- 15.23A: Functions of the Lymphatic System
- 15.23B: The Cardiovascular System
- 15.23C: Structure of the Lymphatic System
- 15.23D: Cardiovascular and Lymphatic System Defenses
- 15.24: Bacterial Diseases of the Cardiovascular and Lymphatic Systems
- 15.24A: Sepsis and Septic Shock
- 15.24B: Bacterial Infections of the Heart
- 15.24C: Rheumatic Fever
- 15.24D: Tularemia
- 15.24E: Brucellosis (Undulant Fever)
- 15.24F: Anthrax
- 15.24G: Gangrene
- 15.25: Viral Diseases of the Cardiovascular and Lymphatic Systems
- 15.25A: Burkitts Lymphoma
- 15.25B: Infectious Mononucleosis
- 15.25C: Other Diseases and Epstein-Barr Virus
- 15.25D: Cytomegalovirus Infections
- 15.25E: Chikungunya Fever
- 15.25F: Classic Viral Hemorrhagic Fevers
- 15.25G: Emerging Viral Hemorrhagic Fevers
- 16: Microbial Ecology
- 16.01: Microbial Ecology
- 16.1A: Microbes and Ecosystem Niches
- 16.1B: Organization of Ecosystems
- 16.1C: Role of Microbes in Biogeochemical Cycling
- 16.1D: Microbial Environments and Microenvironments
- 16.02: Soil and Plant Microbiology
- 16.2A: Soil Composition
- 16.2B: Physical Properties of Soil
- 16.2C: Mycorrhiza
- 16.2D: Wetland Soils
- 16.2E: Endophytes and Plants
- 16.2F: Mycorrhizae- The Symbiotic Relationship between Fungi and Roots
- 16.2F: Plant Pathogens
- 16.2G: Nitrogen Fixation- Root and Bacteria Interactions
- 16.03: Aquatic Microbiology
- 16.3A: Marine Habitats
- 16.3B: Planktonic Communities
- 16.3C: Planktonic Food Webs
- 16.3D: Ocean Floor
- 16.3E: Cold-Seep Ecosystems
- 16.3F: The Deep Sea and Barophilism
- 16.3G: Sea Coral and Sea Anemone Zooxanthellae
- 16.3H: Sponge Communities
- 16.3I: Freshwater Environments
- 16.04: Nutrient Cycles
- 16.4A: Sources and Sinks of Essential Elements
- 16.4B: The Carbon Cycle
- 16.4C: Syntrophy and Methanogenesis
- 16.4D: The Phosphorus Cycle
- 16.4E: The Nitrogen Cycle
- 16.4F: The Sulfur Cycle
- 16.4G: The Iron Cycle
- 16.05: Microbial Symbioses
- 16.5A: Mutualism vs. Symbiosis
- 16.5B: The Rumen and Ruminant Animals
- 16.5C: Hydrothermal Vent Microbial Ecosystems
- 16.5D: Squid-Aliivibrio Symbiosis
- 16.5E: Mutualistic Relationships with Fungi and Fungivores
- 16.5F: Agrobacterium and Crown Gall Disease
- 16.5G: The Legume-Root Nodule Symbiosis
- 16.06: Microbial Bioremediation
- 16.6A: Microbial Ore Leaching
- 16.6B: Petroleum Biodegradation
- 16.6C: The Degradation of Synthetic Chemicals in Soils and Water
- 17: Industrial Microbiology
- 17.01: Industrial Microbiology
- 17.1A: Industrial Microorganisms
- 17.1B: Molecular Products from Microbes
- 17.1C: Primary and Secondary Metabolites
- 17.1D: Large-Scale Fermentations
- 17.02: Microbial Products in the Health Industry
- 17.2A: Industrial Production of Antibiotics
- 17.2B: Vitamins and Amino Acids
- 17.2C: Steroids
- 17.2D: Enzymes Used in Industry
- 17.03: Wastewater Treatment and Water Purification
- 17.3A: Microorganisms and Water Quality
- 17.3B: Wastewater and Sewage Treatment
- 17.3C: Purification of Drinking Water
- 17.04: The Microbiology of Food
- 17.4A: Wine Beer and Alcohol
- 17.4B: Vinegar
- 17.4C: Citric Acid and Other Organic Compounds
- 17.4D: Edible Fungi
- 17.4E: Edible Algae
- 17.4F: Microbes and Dairy Products
- 17.05: Food Preservation
- 17.5A: Fermented Foods
- 17.5B: Food Spoilage by Microbes
- 17.5C: Food Preservation