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Bioinorganic Chemistry

Nguồn ngoài

Bioinorganic Chemistry

This text covers material that could be included in a one-quarter or one-semester course in bioinorganic chemistry for graduate students and advanced undergraduate students in chemistry or biochemistry. The authors believe that such a course should provide students with the background required to follow the research literature in the field. The topics were chosen to represent those areas of bioinorganic chemistry that are mature enough for textbook presentation.

Inorganic ChemistryChemistry
Tác giả
Ivano Bertini, Harry B. Gray, Stephen J. Lippard, and Joan Selverstone Valentine
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Mục lục· 122 mục
  1. 01: Transition-Metal Storage Transport and Biomineralization
  2. 1.01: Biological Significance of Iron Zinc Copper Molybdenum Cobalt Chromium Vanadium and Nickel
  3. 1.02: Biological Systems of Metal Storage
  4. 1.03: Chemical Properties Relative to Storage and Transport
  5. 1.04: Iron Biomineralization
  6. 1.05: Transport of Iron
  7. 1.06: Transport of Zinc Copper Vanadium Chromium Molybdenum and Cobalt
  8. 02: The Reaction Pathways of Zinc Enzymes and Related Biological Catalysts
  9. 2.01: About Carbonic Anhydrase
  10. 2.02: Acid-base Equilibria
  11. 2.03: Catalytic Mechanism
  12. 2.04: Coordinated Water and NMR
  13. 2.05: Coordination Geometries
  14. 2.06: Ester Hydrolysis and Phosphoryl Transfer
  15. 2.07: Group Transfer and Vitamin B-12
  16. 2.08: Metal Substitution
  17. 2.09: Model Chemistry
  18. 2.10: Nucleophilic Addition of (OH-) and (H-)
  19. 2.11: Peptide Hydrolysis
  20. 2.12: pH Dependence of Inhibitor Binding
  21. 2.13: Selecting Zinc
  22. 2.14: Steady-State and Equilibrium Kinetics of Carbonic Anhydrase-Catalyzed (CO 2HCO 3-) Interconversion
  23. 2.15: Strategies for the Investigation of Zinc Enzymes
  24. 2.16: The Natural Catalysts
  25. 2.17: What Do We Learn
  26. 03: Calcium in Biological Systems
  27. 3.01: (Ca2)-binding Proteins in Microorganisms- The Search for a Prokaryotic Calmodulin
  28. 3.02: Basic Facts About Calcium- Its Compounds and Reactions
  29. 3.03: Calcium in Mineralized Tissues
  30. 3.04: Calmodulin
  31. 3.05: Extracellular Calcium Ion-binding Proteins
  32. 3.06: Inositol Trisphosphate and the Calcium Ion Messenger System
  33. 3.07: Intracellular Calcium Ion Transport
  34. 3.08: Measurements of Free Calcium Concentrations
  35. 3.09: Measurements of Total Calcium Concentrations
  36. 3.10: Mitochondrial Calcium Ion Transport
  37. 3.11: Molecular Aspects of Calcium Ion-Regulated Intracellular Processes (Part 1)
  38. 3.12: Molecular Aspects of Calcium Ion-regulated Intracellular Processes (Part 2)
  39. 3.13: Paravalbumin and Calbindins (D 9K) and (D 28K)
  40. 3.14: The Transport and Regulation of (Ca2) Ions in Higher Organisms
  41. 3.15: Troponin C
  42. 003A Front Matter
  43. 01: TitlePage
  44. 02: InfoPage
  45. 03: Table of Contents
  46. 04: Licensing
  47. Preface
  48. 04: Biological and Synthetic Dioxygen Carriers
  49. 4.01: Biological Dioxygen Transport Systems
  50. 4.02: Biological Oxygen Carriers
  51. 4.03: Detailed Structures of Hemoglobins and Model Systems
  52. 4.04: Dioxygen Carriers and Bioinorganic Chemistry
  53. 4.05: General Aspects of the Chemistry of Cobalt
  54. 4.06: General Aspects of the Chemistry of Copper
  55. 4.07: General Aspects of the Chemistry of Dioxygen
  56. 4.08: General Aspects of the Chemistry of Iron
  57. 4.09: General Structural Features that Modulate Ligand Activity
  58. 4.10: Hazards of Life with Dioxygen
  59. 4.11: Nature of the Metal-Dioxygen Linkage in Biological Systems
  60. 4.12: Other Ligands for Biological Oxygen Carriers
  61. 4.13: Requirements for a Model System for Hemoglobin
  62. 4.14: Requirements for Effective Oxygen Carriers
  63. 4.15: Role of the Protein in Effecting Biological Oxygen Transport
  64. 4.16: Selected Chemistry of Dioxygen Iron Copper and Cobalt
  65. 4.17: Stereochemical Changes Upon Ligation
  66. 4.18: Structural Basis of Ligand Affinities of Oxygen Carriers
  67. 4.19: Structures Relevant to Liganded Hemoglobins
  68. 4.20: Thermodynamic Factors
  69. 4.21: Ch. 4 References and Abbreviations
  70. 05: Dioxygen Reactions
  71. 5.01: Catalase and Peroxidase
  72. 5.02: Chemistry of Dioxygen
  73. 5.03: Copper-zinc Superoxide Dismutase
  74. 5.04: Cytochrome c Oxidase
  75. 5.05: Dioxygen Toxicity
  76. 5.06: Monooxygenases
  77. 5.07: Oxygenases
  78. 06: Electron Transfer
  79. 6.01: Biological Redox Components
  80. 6.02: Coupling Electron Transfers and Substrate Activation
  81. 6.03: Electron-transfer Rates
  82. 6.04: Electron-Transfer Theory
  83. 6.05: Energy Storage and Release
  84. 6.06: Long-range Electron Transfer in Proteins (Part 1)
  85. 6.07: Long-range Electron Transfer in Proteins (Part 2)
  86. 6.08: Marcus Theory
  87. 07: Ferrodoxins Hydrogenases and Nitrogenases - Metal-Sulfide Proteins
  88. 7.01: Iron-sulfur Proteins and Models
  89. 7.02: Iron-sulfur Proteins and Models (Part 2)
  90. 7.03: Iron-sulfur Proteins and Models (Part 3)
  91. 7.04: Iron-sulfur Proteins and Models (Part 4)
  92. 7.05: Multisite Redox Enzymes
  93. 7.06: Multisite Redox Enzymes (Part 2)
  94. 7.07: Multisite Redox Enzymes (Part 3)
  95. 7.08: Multisite Redox Enzymes (Part 4)
  96. 7.09: Multisite Redox Enzymes (Part 5)
  97. 7.10: Multisite Redox Enzymes (Part 6)
  98. 7.11: Report on the Nitrogenase Crystal Structure(378-381)
  99. 7.12: Rubredoxin- A Single-Fe Tetrathiolate Protein
  100. 08: MetalNucleic Acid Interactions
  101. 8.01: The Basics
  102. 8.02: The Basics (Part 2)
  103. 8.03: A Case Study- Tris(phenanthroline) Metal Complexes
  104. 8.04: Applications of Different Metal Complexes that Bind Nucleic Acids
  105. 8.05: Applications of Different Metal Complexes that Bind Nucleic Acids (Part 2)
  106. 8.06: Nature's Use of MetalNucleic-acid Interactions
  107. 09: Metals in Medicine
  108. 9.01: Metal Deficiency and Disease
  109. 9.02: Toxic Effects of Metals
  110. 9.03: Aspects of Platinum Binding to DNA
  111. 9.04: Survey of Metals Used for Diagnosis and Chemotherapy
  112. 9.05: Platinum Anticancer Drugs- A Case Study
  113. 9.06: Mapping the Major Adducts of cis- and trans-DDP on DNA Sequence Specificity
  114. 9.07: Structure of Platinum-DNA Complexes
  115. 9.08: Site-specifically Platinated DNA (154)
  116. 9.09: Bioinorganic Chemistry of Platinum Anticancer Drugs- How Might They Work
  117. 9.10: Bioinorganic Chemistry of Platinum Anticancer Drugs How Might They Work (Part 2)
  118. 9.11: Design of New Inorganic Anticancer Drugs
  119. zz3A Back Matter
  120. 10: Index
  121. 20: Glossary
  122. 30: Detailed Licensing