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Chem1102: Drug Discovery - From the Laboratory to the Clinic

Nguồn ngoài

Chem1102: Drug Discovery - From the Laboratory to the Clinic

Medicinal chemistry is a field at the intersection of chemistry, biology, physiology, business, and ethics. This is a course for first-year, non-science major undergraduate students exploring the process of rational drug design, from discovery to use by patients.

Chemistry
Tác giả
Joshua Schrier
Nhà xuất bản
Fordham University
Nguồn
LibreTexts
Ngôn ngữ
EN
Danh mục
Khoa học cơ bản
Đọc trực tuyến Tải PDF (nguồn mở)
Mục lục· 117 mục
  1. 01: Atomic Structure
  2. 1.01: The Elements
  3. 1.02: Atomic Theory
  4. 1.03: The Structure of Atoms
  5. 1.04: Nuclei of Atoms
  6. 1.05: Atomic Masses
  7. 1.06: Arrangements of Electrons
  8. 1.07: The Periodic Table
  9. 1.08: Elements Atoms and the Periodic Table (Summary)
  10. 1.09: Elements Atoms and the Periodic Table (Exercises)
  11. 02: Ionic Bonding and Simple Ionic Compounds
  12. 2.01: Prelude to Ionic Bonding and Simple Ionic Compounds
  13. 2.02: Two Types of Bonding
  14. 2.03: Ions
  15. 2.04: Formulas for Ionic Compounds
  16. 2.05: Ionic Bonding and Simple Ionic Compounds (Exercises)
  17. 2.06: Ionic Bonding and Simple Ionic Compounds (Summary)
  18. 03: Covalent Bonding and Simple Molecular Compounds
  19. 3.01: Prelude to Covalent Bonding and Simple Molecular Compounds
  20. 3.02: Covalent Bonds
  21. 3.03: Covalent Compounds - Formulas and Names
  22. 3.04: Drawing Lewis Structures
  23. 3.05: Characteristics of Covalent Bonds
  24. 3.06: Characteristics of Molecules
  25. 3.07: Organic Chemistry
  26. 3.08: Covalent Bonding and Simple Molecular Compounds (Exercises)
  27. 3.09: Covalent Bonding and Simple Molecular Compounds (Summary)
  28. 04: Noncovalent bonds
  29. 4.01: Intermolecular Interactions
  30. 05: Organic Molecules
  31. 5.01: Structures and Names of Alkanes
  32. 5.02: Branched-Chain Alkanes
  33. 5.03: Condensed Structural and Line-Angle Formulas
  34. 5.04: IUPAC Nomenclature
  35. 5.05: Physical Properties of Alkanes
  36. 5.06: Alkenes- Structures and Names
  37. 5.07: Cis-Trans Isomers (Geometric Isomers)
  38. 5.08: Line Notation (SMILES and InChI)
  39. 06: Lipids
  40. 6.01: Prelude to Lipids
  41. 6.02: Fatty Acids
  42. 6.03: Fats and Oils
  43. 6.04: Membranes and Membrane Lipids
  44. 6.05: Steroids
  45. 6.06: Exercises
  46. 6.07: Lipids (Summary)
  47. 07: Conformations and Stereochemistry
  48. 7.01: Prelude to Conformations and Stereochemistry
  49. 7.02: Conformations of open-chain organic molecules
  50. 7.03: Chirality and stereoisomers
  51. 7.04: Naming chiral centers- the R and S system
  52. 7.05: Optical Activity
  53. 7.06: Compounds with multiple chiral centers
  54. 7.07: Stereochemistry of alkenes
  55. 7.08: Stereochemistry in biology and medicine
  56. 08: Acids and Bases
  57. 8.01: Prelude to Acids and Bases
  58. 8.02: Brnsted-Lowry Definition of Acids and Bases
  59. 8.03: Water - Both an Acid and a Base
  60. 8.04: The Strengths of Acids and Bases
  61. 8.05: Buffers
  62. 8.06: Acids and Bases (Exercises)
  63. 8.07: Acids and Bases (Summary)
  64. 09: Amino Acids Proteins and Enzymes
  65. 9.01: Prelude to Amino Acids Proteins and Enzymes
  66. 9.02: Properties of Amino Acids
  67. 9.03: Reactions of Amino Acids
  68. 9.04: Peptides
  69. 9.05: Proteins
  70. 9.06: X-ray Protein Crystallography
  71. 9.07: Enzymes
  72. 9.08: Enzyme Action
  73. 9.09: Enzyme Activity
  74. 9.10: Enzyme Inhibition
  75. 9.11: Enzyme Cofactors and Vitamins
  76. 9.12: Amino Acids Proteins and Enzymes (Exercises)
  77. 9.13: Amino Acids Proteins and Enzymes (Summary)
  78. 10: Equilibrium and Kinetics- Making Drugs Stick
  79. 10.01: Prelude--A Drug's Life (in your Body)
  80. 10.02: A Quick Review of Thermodynamics and Kinetics
  81. 10.03: Catalysis
  82. 10.04: Pharmacology as an Equilibrium and Kinetics Problem
  83. 11: Molecular Genetics
  84. 11.01: Prelude to Nucleic Acids
  85. 11.02: Nucleotides
  86. 11.03: Nucleic Acid Structure
  87. 11.04: Replication and Expression of Genetic Information
  88. 11.05: Protein Synthesis and the Genetic Code
  89. 11.06: Mutations and Genetic Diseases
  90. 11.07: Viruses
  91. 11.08: Nucleic Acids (Exercises)
  92. 11.09: Nucleic Acids (Summary)
  93. 12: Chemical and Biological Databases
  94. 12.01: Public Chemical Databases
  95. 12.02: Data Organization in PubChem as a Data Aggregator
  96. 12.03: Database Query Introduction
  97. 12.04: PubChem Web Interfaces for Text
  98. 12.05: Text Search in PubChem
  99. 12.06: Additional Data Retrieval Approaches in PubChem
  100. 12.07: Searching PubChem Using a Non-Textual Query
  101. 13: Computer-Aided Drug Design
  102. 13.01: Reading
  103. 13.02: How to Dock Your Own Drug
  104. 14: Does it work Clinical Testing
  105. 14.01: Understanding Clinical Trial Types (Video)
  106. 14.02: Statistical Basics
  107. 14.03: Random Sampling
  108. 14.04: Clinical Studies
  109. 14.05: Types of clinical interventions
  110. 14.06: Evolution of new intervention products and sequence of study phases
  111. 14.07: Interpreting Clinical Research
  112. 15: What is it worth Estimating Value
  113. 15.01: Types of economic analyses of health interventions
  114. 15.02: The Time Value of Money
  115. 15.03: Calculating the Relationship of Time and Value
  116. 16: Appendix
  117. 16.01: Getting started with Zotero