
Nguồn ngoài
Molecular Genetics 4606
Molecular Genetics is a comprehensive genetics course for molecular genetics majors or biological sciences majors with a genetics focus. Students will integrate genetic, biochemical, and cell-biological data to interpret the normal function of a gene, interpret how mutations affect gene function, and interpret interactions between different genes. Topics include all aspects of transmission genetics and gene biology, including DNA replication, transcription and translation.
- Tác giả
- Helen Chamberlin
- Nhà xuất bản
- The Ohio State University
- Nguồn
- LibreTexts
- Ngôn ngữ
- EN
- Danh mục
- Khoa học cơ bản
Mục lục· 119 mục
- 01: The Cell Cycle
- 1.01: The Cell Cycle and Changes in DNA Content
- 1.02: Bacterial Cell Division and the Eukaryotic Cell Cycle
- 1.03: Regulation of the Cell Cycle
- 02: Mitosis and Meiosis
- 2.01: Mitosis
- 2.02: Meiosis
- 2.03: Mitosis and Meiosis
- 03: Alleles and Probabilities
- 3.01: Genes are the Basic Units of Inheritance
- 3.02: Model Organisms Facilitate Genetic Advances
- 3.03: Mendels First Law
- 3.04: Biochemical Basis of Dominance
- 3.05: Crossing Techniques Used in Classical Genetics
- 3.06: Dihybrid Crosses
- 3.07: Why Use Nomenclature
- 3.08: Basic Nomenclature
- 3.09: Linked Genes
- 04: Hypothesis Testing
- 4.01: Phenotypic Ratios May Not Be As Expected
- 4.02: Probability
- 4.03: Chi-Square Test of Goodness-of-Fit
- 05: Sex Determination Chromosomes and Linkage
- 5.01: Karyotypes Describe Chromosome Number and Structure
- 5.02: Sex-Linkage- An Exception to Mendels First Law
- 06: Pedigrees
- 6.01: Pedigree Analysis
- 6.02: Inferring the Mode of Inheritance
- 6.03: Sporadic and Non-Heritable Diseases
- 6.04: Calculating Probabilities
- 07: Multiple Gene Alleles
- 7.01: Relationships Between Genes Genotypes and Phenotypes
- 7.02: Complementation tests and Allelism
- 08: Gene Interactions and Epistasis
- 8.01: Epistasis and Other Gene Interactions
- 8.02: Example of Multiple Genes Affecting One Character
- 09: Genetic Pathways
- 9.01: Genetic Pathways
- 10: Nucleic Acids
- 10.01: DNA is the Genetic Material
- 10.02: The Structure of DNA
- 10.03: DNA- The Genetic Material
- 11: Amplifying and Manipulating DNA Fragments
- 11.01: Prelude to Molecular Genetics
- 11.02: Isolating Genomic DNA
- 11.03: Isolating or Detecting a Specific Sequence by PCR
- 11.04: PCR and Gel Electrophoresis
- 11.05: Origins of Molecular Polymorphisms
- 11.06: Classification and Detection of Molecular Markers
- 11.07: Cutting and Pasting DNA- Restriction Digests and DNA Ligation
- 11.08: Make and Screen a cDNA Library
- 11.09: DNA Sequencing
- 11.10: Genomic Libraries
- 11.11: The Polymerase Chain Reaction (PCR)
- 12: Evaluating Recombinant DNA
- 12.01: Cloning DNA - Plasmid Vectors
- 12.02: DNA Analysis - Gel Electrophoresis
- 12.03: Recombinant DNA Technology
- 13: Detecting Genes and Gene Products
- 13.01: DNA Analysis- Blotting and Hybridization
- 14: DNA Replication
- 14.01: DNA Structure
- 14.02: Genes and Chromatin in Eukaryotes
- 14.03: Introduction
- 14.04: DNA Replication
- 14.05: DNA- The Genetic Material
- 15: Transcription
- 15.01: Introduction
- 15.02: Overview of Transcription
- 15.03: Details of Transcription
- 16: Transcriptional Regulation (prokaryotes)
- 16.01: The lac Operon
- 16.02: The Use of Mutants to Study the lac Operon
- 16.03: Gene Regulation in Prokaryotes
- 17: RNA processing
- 17.01: Details of Eukaryotic mRNA Processing
- 17.02: Gene Expression- Transcription
- 18: Transcriptional Regulation (eukaryotes)
- 18.01: Eukaryotic Gene Regulation
- 18.02: Regulatory Elements in Evolution
- 18.03: Additional Levels of Regulating Transcription
- 18.04: Gene Regulation in Eukaryotes
- 18.05: Transgenic organisms
- 19: Small RNAs
- 19.01: Post-transcriptional Control of Gene Expression
- 20: The Genetic Code
- 20.01: The Function of Genes
- 20.02: An Overview of the Genetic Code
- 20.03: Gene and Protein Colinearity and Triplet Codons
- 20.04: Translation
- 20.05: Gene Expression- Translation
- 20.06: Gene Expression- Applied Example (Part 1)
- 21: Alleles and Gene Function
- 21.01: Types of Mutations
- 21.02: DNA Mutations
- 22: Cancer Genetics
- 22.01: Classification of Cancers
- 22.02: Cancer Cell Biology
- 22.03: Hallmarks of Cancer
- 22.04: Mutagens and Carcinogens
- 22.05: Oncogenes
- 22.06: Tumor Suppressor Genes
- 22.07: The Poster Boy of Genetic Research Leading to a Cancer Treatment Gleevec (Imatinib)
- 23: Genomics
- 23.01: Omics Technologies
- 23.02: DNA Sequencing
- 23.03: Whole Genome Sequencing
- 24: Functional Genomics
- 24.01: Functional Genomics Determining Function(s)
- 24.02: Genomic Approaches- The DNA Microarray
- 25: Genetic Linkage
- 25.01: Linkage
- 25.02: Recombination
- 25.03: Linkage Reduces Recombination Frequency
- 25.04: Crossovers Allow Recombination of Linked Loci
- 25.05: Inferring Recombination From Genetic Data
- 25.06: Genetic Mapping
- 26: Genetic Maps
- 26.01: Mapping With Three-Point Crosses